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Many of the critical immune/inflammatory initiating markers (eg. TNF, IFN, IL-1, IL-2, IL-4, IL-6) are primary candidates for inclusion in study assay panels, because of their dominant actions. However, these initiating markers are typically exist at low abundance levels and below the level of quantification of many standard immunoassays.
Why is assay sensitivity so important in demonstration of efficacy and mechanism?
By increasing assay sensitivity Aeirtec increases the capacity for capturing low abundance critical markers by an order of magnitude.
Aeirtec achieves this through the following patented and proprietary designs:
(1) An Aeirtec-designed buffer that reduces assay ‘noise’ from nonspecific binding
and heterophilic antibody activity
(2) A second Aeirtec-designed buffer that generates calibration curves that match the sample-containing fluid behaviour (matrix matched)
(3) A method of calibration curve generation and curve fitting that provides optimised interpolation at lower concentrations
See illustration below